Etoricoxib

Overview

What is Etoricoxib?   

Etoricoxib is a selective COX-2 inhibitor used primarily as an anti-inflammatory agent to relieve pain and swelling associated with various conditions. It belongs to a class of medications known as nonsteroidal anti-inflammatory drugs (NSAIDs), but it specifically targets the COX-2 enzyme, reducing the likelihood of stomach ulcers and other gastrointestinal side effects typically associated with traditional NSAIDs. 

Etoricoxib is synthetically produced and designed to selectively inhibit the cyclooxygenase-2 (COX-2) enzyme, which is involved in the inflammatory process, while sparing cyclooxygenase-1 (COX-1), which protects thereby preserving the acid-protective barrier of the stomach lining. 

Global Name

• Generic name: Etoricoxib
• Brand names: Arcoxia, Algix, Tauxib, and others 

Usage

What is Etoricoxib used for? 

Etoricoxib is used to treat: 

• Osteoarthritis 

• Rheumatoid arthritis 

• Gouty arthritis 

• Ankylosing spondylitis 

• Other conditions associated with high levels of inflammation and pain 

How do you use Etoricoxib? 

Availability: 

 Etoricoxib is available in tablet form. 

Dosage information: 

• Adults:  

• Osteoarthritis: 60 mg once daily 

• Rheumatoid arthritis and ankylosing spondylitis: 60 mg once daily as starting dose, option to increase to 90 mg once daily, if necessary 

• Acute gout: 120 mg once daily, for up to 8 days 

• Elderlies: No dosage adjustment is generally necessary but should be used with caution. 

Are the following suitable to take Etoricoxib: Children, adults, elderlies? 

• Children: Not recommended for use in children. 

• Adults: Suitable for adults under medical advice. 

• Elderlies: Use with caution, especially in those with reduced kidney or liver function. 

Is there anyone who can’t take Etoricoxib? 

• Children: Not suitable for children. 

• Adults: Contraindicated in adults with severe heart disease, uncontrolled hypertension, or those who have had recent major heart surgeries. 

• Elderlies: Caution is advised, particularly in those with pre-existing kidney, liver, or heart conditions. 

• Pregnancy: Should not be used during pregnancy unless necessary. 

• Lactation: Not recommended as it is not known if Etoricoxib passes into breast milk. 

Allergies: Should not be taken by people allergic to Etoricoxib or any other component of the drug. 

Warnings and precautions: Should be used with caution in patients with a history of stomach ulcers or gastrointestinal bleeding and increased risk of major cardiovascular events. 

Interactions and contraindications of the drug: 

• Interacts with: Warfarin, diuretics, ACE inhibitors, and lithium. 

• Conditions: Not suitable for use in patients with severe hepatic dysfunction or inflammatory bowel disease. 

Side Effects

Potential side effects include: 

• Stomach pain 

• Dizziness 

• Headache 

• Hypertension 

• Rare but severe: Stroke or heart attack 

Pharmacist Tips

Availability

Where is Etoricoxib available in Hong Kong?

 Etoricoxib is a prescription medication that can be prescribed by healthcare providers. 

FAQs

How long does it take for Etoricoxib to work? 

You may begin to feel relief within 24 hours, but it may take longer for the full effect. 

Can I take Etoricoxib with other pain relievers? 

Avoid taking other NSAIDs concurrently. Discuss any additional medications with your healthcare provider. 

What should I do if I miss a dose? 

Take it as soon as you remember but skip the missed dose if it is almost time for your next scheduled dose. 

Is Etoricoxib safe for long-term use? 

Long-term use can increase the risk of gastrointestinal and cardiovascular events. It should be used at the lowest effective dose for the shortest duration possible.