Mefenamic Acid

Overview

What is Mefenamic Acid?   

Mefenamic Acid(甲芬那酸) is a non-steroidal anti-inflammatory drug (NSAID) used primarily to treat mild to moderate pain and inflammation. It belongs to the fenamate class of NSAIDs and is effective in reducing pain, inflammation, and fever. 

 
Quick breakdown of the drug’s structure, how it is made: 

Mefenamic Acid is synthesised through chemical processes that result in its active form, capable of inhibiting the enzymes responsible for inflammation and pain, primarily cyclooxygenase (COX) enzymes. 

Global Name

• Generic name: Mefenamic Acid 
• Brand name: Ponstel, Parkemed, Ponstan, Ponalar

Usage

What is Mefenamic Acid used for? 

Mefenamic Acid is used to treat: 

• Pain from various conditions, including menstrual pain 

• Inflammatory conditions like arthritis 

• Fever associated with various inflammatory conditions (with caution and only on strict medical advice) 

How do you use Mefenamic Acid? 

Availability: 
Mefenamic Acid is available in capsule, tablet and oral suspension form. 

Dosage information: 

• Adults and children over 14 years: 500 mg three times a day with food, as initial dose for acute pain.

• Maintenance dose: 250 mg every 6 hours as needed. 

Are the following suitable for getting the drug 

• Children: Not recommended for children under 14 years. 

• Adults: Suitable for adults. 

• Elderlies: Use with caution due to increased risk of adverse effects, such as gastrointestinal and kidney issues. 

Is there anyone who shouldn’t get the drug?   

• Children: Not suitable for children under 14 years. 

• Adults: Individuals with known allergy to NSAIDs. 

• Elderlies: Increased caution due to potential for more severe side effects. 

• Pregnancy: Not recommended, especially in the third trimester due to risk of complications. 

• Lactation: Consult a healthcare provider before use. 

Allergies: People with allergies to aspirin or other NSAIDs should avoid Mefenamic Acid.

Warnings and Precautions: 

Interactions and contraindications of Mefenamic Acid: 

• Interacts with: Blood thinners, lithium, methotrexate, and other drugs. 

• Conditions: Avoid in patients with active gastrointestinal bleeding, ulcer disease, or kidney and heart failure. 

Side Effects

Possible side effects include: 

• Gastrointestinal problems like ulcers and bleeding 

• Headache, dizziness, and drowsiness 

• Hypertension and fluid retention 

 Serious side effects may include: 

• Cardiovascular thrombotic events 

• Massive gastrointestinal bleeding 

• Gastro-duodenal perforation 

• Liver damage/failure 

• Renal damage/failure 

Pharmacist Tips

• Storage information: Store at room temperature, away from moisture and heat. 

• Handling instructions: Handle carefully and ensure the cap is closed tightly after use to prevent moisture ingress.

Availability

Where is Mefenamic Acid available in Hong Kong?

Mefenamic Acid is a prescription medication that can be prescribed by healthcare providers. 

FAQs

How long can I take Mefenamic Acid for pain relief? 

It is generally used for short-term treatment, not exceeding 7 days, unless advised by a healthcare provider. 

Can Mefenamic Acid be taken on an empty stomach?   

No, it should be taken with food and/or a gastroprotective agent (like antacids, H2-blockers and proton pump inhibitors) to minimise gastrointestinal side effects. 

What should I do if I miss a dose? 

Take the missed dose as soon as you remember but skip it if it's almost time for the next scheduled dose. 

Can I stop taking Mefenamic Acid immediately after pain relief? 

Yes, Mefenamic Acid can be stopped when pain and inflammation are managed, but always consult with a healthcare provider before making any changes to medication use.