Simvastatin

Overview

What is Simvastatin?   

Simvastatin is a lipid-lowering medication that belongs to the statin class of drugs. It is primarily used to control elevated cholesterol or triglycerides. The active ingredient, simvastatin, works by inhibiting an enzyme necessary for the production of cholesterol in the liver, thereby reducing the overall cholesterol levels in the body. 

Simvastatin is synthesised through a fermentation process involving the bacterium Aspergillus terreus. The compound specifically targets the HMG-CoA reductase pathway, which is crucial in the body's synthesis of cholesterol. 

Global Name

• Generic name: Simvastatin  
• Brand names: Zocor, Simlup, Simcard, and others

Usage

What is Simvastatin used for? 

Simvastatin is used to treat: 

• High cholesterol (hypercholesterolemia) 

• Prevention of cardiovascular diseases 

• Reducing the risk of heart attack and stroke in individuals with diabetes or coronary heart disease 

• Secondary prevention of cardiovascular events post-coronary artery bypass & grafting (CABG) surgery  

How do you use Simvastatin? 

Availability:

Simvastatin is available in tablet form. 

Dosage information: 

• Adults: Typically, the initial dose is 20-40 mg once daily in the evening. 

• Elderlies: Start with a lower dose due to the increased risk of muscle problems. 

• Children (10 years and older): Doses start at 10 mg daily. 

Are the following suitable to take Simvastatin: Children, adults, elderlies? 

• Children: Suitable for children aged 10 years and older. 

• Adults: Suitable for adults under medical advice. 

• Elderlies: Use with caution, starting at a lower dose. 

Is there anyone who can’t take Simvastatin? 

• Children: Not recommended for children under 10 years. 

• Adults: Those with active liver disease or unexplained persistent elevations in hepatic transaminase levels. 

• Elderlies: Caution is needed due to the increased risk of muscle-related side effects. 

• Pregnancy: Contraindicated as it may affect fetal development. 

• Lactation: Not recommended as it may pass into breast milk and could harm a nursing baby. 

Allergies: People allergic to any component of Simvastatin should avoid it. 

Warnings and precautions: Should not be taken with grapefruit juice as it increases the drug concentration in the blood, potentially leading to adverse effects. 

Interactions and contraindications of the drug: 

• Interacts with: Certain antibiotics, antifungals, HIV protease inhibitors, and other cholesterol-lowering treatments. 

• Conditions: Avoid in patients with liver disease and regulate use in those with diabetes or thyroid disorders. 

Side Effects

Common side effects include: 

• Headaches 

• Nausea 

• Muscle pain 

• Increased risk of diabetes 

• Rare but severe: Liver failure, rhabdomyolysis 

Pharmacist Tips

Availability

Where is Simvastatin available in Hong Kong?

 Simvastatin is a prescription medication that can be prescribed by healthcare providers. 

FAQs

Can Simvastatin be taken in the morning? 

It is recommended to take Simvastatin in the evening as the body’s cholesterol synthesis increases during the night. 

What should I do if I experience muscle pain while taking Simvastatin? 

Report any unexplained muscle pain, tenderness, or weakness to your doctor immediately as it could be a sign of a serious side effect. 

Can I drink alcohol while taking Simvastatin? 

Drinking alcohol can increase the risk of liver problems, so it is best to limit alcohol consumption. 

How long does it take for Simvastatin to work? 

Significant improvements in cholesterol levels can usually be seen within 4-6 weeks of treatment.