Terbinafine

Overview

What is Terbinafine?   

Terbinafine is an antifungal medication primarily used to treat fungal infections of the skin and nails. It works by inhibiting the enzyme squalene epoxidase, which is involved in the fungal cell membrane synthesis pathway. This action leads to a deficiency in ergosterol, an essential component of fungal cell membranes, causing the fungal cells to die and thus treating the infection. 

Terbinafine is a synthetic allylamine antifungal. It is chemically manufactured and specifically formulated to disrupt fungal cell membrane growth by blocking the squalene epoxidase enzyme. 

Global Name

• Generic name: Terbinafine
• Brand names: Lamisil, Terbinex, Terbisil, and others 

Usage

What is Terbinafine used for? 

Terbinafine is used to treat a variety of fungal infections including: 

• Athlete's foot (tinea pedis) 

• Jock itch (tinea cruris) 

• Ringworm (tinea corporis) 

• Fungal nail infections (onychomycosis) 

How do you use Etoricoxib? 

Availability: 

Terbinafine is available in tablet form, topical cream, gel and spray. 

Dosage information: 

• Tablets:  

• Adults: 250 mg once daily for 6 weeks (fingernail) or 12 weeks (toenail) 

• Cream/Gel:  

• Adults and Children: Apply to the affected area once or twice daily for 1 to 4 weeks, depending on the severity of the infection. 

Are the following suitable to take Terbinafine: Children, adults, elderlies? 

• Children: Suitable for children over 12 years old, under medical advice and adult supervision. 

• Adults: Suitable for use. 

• Elderlies: Can be used, but with caution, especially in those with pre-existing liver or kidney issues. 

Is there anyone who can’t take Terbinafine? 

• Children: Not recommended for children under 12 years without medical advice (per product package insert). 

• Adults: Should not be used by individuals with chronic or active liver disease or elevated liver enzymes. 

• Elderlies: Caution advised due to potential for increased systemic absorption and pre-existing liver condition. 

• Pregnancy: Use only if clearly needed and the potential benefit justifies the potential risk. 

• Lactation: Not recommended as Terbinafine can pass into breast milk. 

Allergies: Individuals with known sensitivity to Terbinafine or to any of its excipients should avoid using this medication. 

Warnings and precautions: Liver function tests are advised before starting treatment as Terbinafine has been associated with liver dysfunction. 

Interactions and contraindications of the drug: 

• Interacts with: Drugs metabolised by CYP2D6 such as beta-blockers, SSRIs, and MAO inhibitors. 

• Conditions: Avoid in patients with liver disease or renal impairment. 

Side Effects

Possible side effects include: 

• Headache 

• Gastrointestinal upset 

• Rash 

• Serious but rare: Liver failure 

Pharmacist Tips

Availability

Where is Terbinafine available in Hong Kong?

Terbinafine is a prescription medication that can be prescribed by healthcare providers. 

FAQs

How quickly does Terbinafine work? 

Improvement in symptoms can be seen in a few weeks, but the full course should be completed to prevent recurrence. 

Can I drink alcohol while taking Terbinafine tablets? 

Alcohol can increase the risk of liver damage, and it is generally recommended to avoid alcohol during treatment. 

Is Terbinafine safe during pregnancy? 

Terbinafine should only be used during pregnancy when absolutely necessary, as potential risks need to be weighed against benefits. 

Can Terbinafine treat all types of fungal infections? 

Terbinafine is effective against many fungal infections, particularly those of the skin and nails, but it may not be suitable for all types of fungal infections. Consult a healthcare provider for advice.